Landon Donovan american professional footballer is one of the most successful players in MLS League. Donovan score most goals in the league then any other player. The second player who made his name among the leading goal scorers of Major League Soccer is (Jeff Cunningham). He scored 134 goals in all his match appearance since 1998-2010. MLS is way different from European football leagues.
| Players | Goals | Team | Years |
| Landon Donovan | 145 | LA Galaxy | 2001–2016 |
| Jeff Cunningham | 134 | Columbus Crew, FC Dallas | 1998–2010 |
| Jaime Moreno | 133 | D.C. United | 1996–2010 |
| Chris Wondolowski | 126 | San Jose Earthquakes | 2004 (Present) |
| Ante Razov | 114 | Chivas USA, Chicago Fire | 1996-2009 |
| Jason Kreis | 108 | Dallas Burn, Real Salt Lake | 1996–2007 |
| Dwayne De Rosario | 104 | Toronto F.C, San Jose Earthquakes | 2001–2014 |
| Taylor Twellman | 101 | New England Revolution | 2002–2010 |
| Edson Buddle | 100 | Columbus Crew, LA Galaxy | 2001-2015 |
| Carlos Ruiz | 89 | FC Dallas, LA Galaxy | 2016 (Present) |
The 34 year old footballer (Chris Wondolowski) is currently active and playing his career in MLS League. If he some how managed to scored more then 14 goals he will join the top three scoring leaders of league. Landon Donovan managed to get this record by playing almost 334 matches for the clubs in MLS league. Jaime Moreno scored 133 goals in 340 match appearances.
Dwayne De Rosario only Canadian player who made to the most goals list of Major Soccer League. He scored most goals while playing for the clubs (Toronto FC, San Jose Earthquakes and Houston Dynamo).