Lionel Messi one of the best footballers in the world created the record most goals in LA Liga career. He is joined by Cristiano Ronaldo in the list of highest goals, Ronaldo who joins the league in 2009, become the second player to score more then 250 goals in the La Liga after Messi. Before them its Telmo Zarra who sets the record during his career with club (Athletic Bilbao) he scored 251 goals in 278 match appearances and created the history in Spanish La Liga.
But if we see the goal scoring ratio of these players then its Ronaldo who got excellent goal scoring form. He scored 1 goal per match with the ratio of (1.08). Raul who played a big career at Real Madrid club come closer to break the record but he can only (228) in all 550 club games for the Madrid since 1994 to 2010.
| Players | Goals | Appearances | Year | Team |
| Lionel Messi | 349 | 382 | 2004 | Barcelona |
| Cristiano Ronaldo | 285 | 265 | 2009 | Real Madrid |
| Telmo Zarra | 251 | 278 | 1940–1955 | Athletic Bilbao |
| Hugo Sanchez | 234 | 347 | 1981–1994 | Real Madrid, Atlético Madrid |
| Raul | 228 | 550 | 1994–2010 | Real Madrid |
| Alfredo Di Stéfano | 227 | 328 | 1953–1966 | Real Madrid |
| Juan Arza | 227 | 349 | 1943–1959 | Sevilla |
| César Rodríguez | 223 | 353 | 1939–1955 | Barcelona |
| Quini | 219 | 448 | 1970–1987 | Sporting Gijón |
| Pahiño | 210 | 278 | 1943–1956 | Real Madrid, Celta |
| Edmundo Suárez | 195 | 231 | 1939–1950 | Valencia, Alcoyano |
| Carlos Santillana | 186 | 461 | 1970–1988 | Real Madrid |
| David Villa | 185 | 352 | 2003–2014 | Valencia, Barcelona |
| Guillermo Gorostiza | 178 | 256 | 1929–1945 | Valencia, Athletic Bilbao |